DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism.
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چکیده
منابع مشابه
The hydrolysis of N-benzoyl-DL-tyrosylglycinamide, N-acetyl-L-tyrosylglycinamide, and N-acetyl-DL-tyrosylglycinamide by chymotrypsin.
Contrary to the report of Bergmann and Fruton (1) the L peptide present in aqueous solutions of N-benzoyl-DL-tyrosylglycinamide, prepared by two independent methods, is rapidly hydrolyzed by crystalline chymotrypsin. At 40” and pH 7.8 in a 0.00344 M solution’ of the DL mixture the L component is hydrolyzed as rapidly as in a 0.00172 M solution of the L peptide (Table I). Because of the relative...
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Plasma amino acid response of wethers to abomasal infusions of DL-methionine (DLM), DL-homocysteine thiolactone-HCl (HCTL) and N-acetyl-DL-methionine (NAM), in vivo rumen stability of the latter two methionine analogs and preintestinal absorption of HCTL were studied. The daily infusion of 1.06 g of DLM elevated molar percentage of methionine and lysine in plasma'and decreased molar percentage ...
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There are many query languages (QLs) that can be used to query RDF and OWL ontologies but neither type is satisfactory for querying OWL-DL ontologies. RDF-based QLs (RDQL, SeRQL, SPARQL) are harder to give a semantics w.r.t. OWL-DL and are more powerful than what OWL-DL reasoners can provide. DL-based QLs (DIG ask queries, nRQL) have clear semantics but are not powerful enough in the general ca...
متن کاملStructure and function of carnitine acyltransferases.
Carnitine acyltransferases catalyze the exchange of acyl groups between carnitine and coenzyme A (CoA). These enzymes include carnitine acetyltransferase (CrAT), carnitine octanoyltransferase (CrOT), and carnitine palmitoyltransferases (CPTs). CPT-I and CPT-II are crucial for the beta-oxidation of long-chain fatty acids in the mitochondria by enabling their transport across the mitochondrial me...
متن کاملCharacterization and properties of carnitine acyltransferases.
lysine metabolism has been measured in rats fed a diet low in trimethyl-lysine and carnitine (Davis & Hoppel, 1983, 1986). Under these steady-state conditions, the total body trimethyl-lysine content is similar to the total body carnitine content. The tissue distribution of peptide-linked and free trimethyl-lysine shows that approximately 68% of the total trimethyl-lysine is present in skeletal...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)38636-2